In Vivo Evaluation of Acute and Subacute Toxicity of Jatropha curcas Seed Oil

Medicinal plants are regarded as safe because of their natural origin, nevertheless, they can contain toxic substances that exert adverse effects. This study aims to evaluate acute and subacute toxicity Jatropha curcas seed oil using modified Lorke method 28 days repeated dosing grouped rats with normal saline -10, 300, 600 mg/kg body weight the oil. At end experimentation, haematological biochemical analysis blood samples histopathology liver kidney in each group were evaluated. The Lethal Dose (LD50) J. was lower than 5000mg/kg b.wt. Haematological showed a dose-dependent decrease Hemoglobin, Packed Cell Volume Red Blood Cells, an increase level Total White Count Platelet Count, Aspartate aminotransferase, Alanine Alkaline phosphatase, urea creatinine treated groups, while histological evaluation revealed distortion cytoarchitecture administered b.wt found less at phase but there manifestation causing effects on haematological, parameters tissues liver. suggests be used, caution should exercised when it high doses for prolonged periods.